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KMID : 0616120220530010049
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Korean Journal of Pharmacognosy
2022 Volume.53 No. 1 p.49 ~ p.56
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Anti-inflammatory and Anti-nociceptive Effects of Ethyl Acetate Fraction of Lindera glauca
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Kim Jong-Soo
Kim Bo-Hye
Park Seung-Ju
Yang Woo-In
Kim Myung-Soo
Lee Byung-Soo
Cha Dong-Seok
Lee Se-Youn
Kwon Jin
Jeon Hoon
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Abstract
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The present study was designed to evaluate the anti-inflammatory and anti-nociceptive potential of the ethyl acetate fraction of Lindera glauca (ELG). We found that ELG significantly suppressed NO production through decreased enzyme activity and expression of iNOS in the IFN-γ/LPS-activated murine peritoneal macrophages. The treatment of ELG also down-regulated the expression of COX-2. Our western blot data revealed that inhibitory effects of ELG on these pro-inflammatory mediators were attributed to inactivation of NF-κB. In addition, ELG-fed mice showed a marked decrease in paw edema induced by subplantar injection of trypsin, suggesting in vivo anti-inflammatory potential of ELG. We further investigated the anti-nociceptive properties of ELG using thermal and chemical nociception model. We found that ELG has a strong anti-nociceptive activities in both central and peripheral mechanism. An additional combination test with naloxone revealed that opioid receptor was not involved in the ELG-mediated anti-nociception. In conclusion, ELG may possibly be used as valuable anti-inflammatory and anti-nociceptive agent for the treatment of inflammatory diseases and pains.
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KEYWORD
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Lindera glauca, Anti-inflammatory, Anti-nociceptive
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